This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ehrhardt, S.
Right arrow Articles by Mockenhaupt, F. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ehrhardt, S.
Right arrow Articles by Mockenhaupt, F. P.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, September 2007, p. 3407-3409, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00179-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Large-Scale Surveillance of Plasmodium falciparum crt(K76T) in Northern Ghana{triangledown}

Stephan Ehrhardt,1* Teunis A. Eggelte,2 Sarah Kaiser,3 Lydia Adjei,3 Gerd D. Burchard,4 Sylvester D. Anemana,5 Ulrich Bienzle,3 and Frank P. Mockenhaupt3

Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany,1 Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Centre, Amsterdam, The Netherlands,2 Institute of Tropical Medicine and International Health, Charité-University Medicine Berlin, Berlin, Germany,3 Section of Tropical Medicine and Infectious Diseases, Medical Department I, University Hospital Hamburg-Eppendorf, Hamburg, Germany,4 Regional Health Administration, Ministry of Health, Takoradi, Ghana5

Received 7 February 2007/ Returned for modification 30 May 2007/ Accepted 4 June 2007

Surveillance of Plasmodium falciparum crt(K76T) [Pfcrt(K76T)], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%. Pfcrt(K76T) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season. Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in artemisinin combination therapy.

* Corresponding author. Mailing address: Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany. Phone: 49-(0)40-42818-373. Fax: 49-(0)40-42818-394. E-mail: ehrhardt{at}bni-hamburg.de

{triangledown} Published ahead of print on 11 June 2007.

Antimicrobial Agents and Chemotherapy, September 2007, p. 3407-3409, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00179-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»