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Antimicrobial Agents and Chemotherapy, September 2007, p. 3434-3436, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.01567-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

In Vivo Efficacy of a Novel Oxazolidinone Compound in Two Mouse Models of Infection{triangledown}

Charles J. Gill,* George K. Abruzzo, Amy M. Flattery, Andrew S. Misura, Ken Bartizal, and Emily J. Hickey

Department of Infectious Diseases, Merck Research Laboratories, Rahway, New Jersey 07065

Received 18 December 2006/ Returned for modification 17 January 2007/ Accepted 22 June 2007

A novel oxazolidinone, AM 7359, was evaluated in two mouse models of Staphylococcus aureus infection. AM 7359 and linezolid were equally efficacious in a methicillin-susceptible S. aureus organ burden model and a methicillin-resistant S. aureus localized infection model. However, AM 7359 was eightfold more efficacious than linezolid against a linezolid- and methicillin-resistant S. aureus strain in this localized (thigh) infection model.

* Corresponding author. Mailing address: R80Y-265, Merck & Co., Inc., P.O. Box 2000, Rahway, NJ 07065. Phone: (732) 594-6053. Fax: (732) 594-1298. E-mail: charles_gill{at}merck.com

{triangledown} Published ahead of print on 2 July 2007.

Antimicrobial Agents and Chemotherapy, September 2007, p. 3434-3436, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.01567-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Hilliard, J. J., Fernandez, J., Melton, J., Macielag, M. J., Goldschmidt, R., Bush, K., Abbanat, D. (2009). In Vivo Activity of the Pyrrolopyrazolyl-Substituted Oxazolidinone RWJ-416457. Antimicrob. Agents Chemother. 53: 2028-2033 [Abstract] [Full Text]  


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