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Antimicrobial Agents and Chemotherapy, September 2007, p. 3437-3439, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00130-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

In Vivo Activity of a Novel Polymeric Guanidine in Experimental Skin Infection with Methicillin-Resistant Staphylococcus aureus{triangledown}

Christina Kratzer,1 Selma Tobudic,1 Karin Macfelda,2 Wolfgang Graninger,1 and Apostolos Georgopoulos1*

Department of Internal Medicine I, Division of Infectious Diseases and Tropical Diseases,1 Care Unit for Biomedical Research, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria2

Received 29 January 2007/ Returned for modification 16 March 2007/ Accepted 20 June 2007

The in vivo efficacy of the novel polymeric guanidine AKACID Plus was evaluated in a guinea pig model of experimental skin infection with methicillin-resistant Staphylococcus aureus (MRSA). Topical application of AKACID Plus at concentrations of ≥0.5% was as effective as mupirocin 2% cream in the treatment of superficial skin infection with MRSA.

* Corresponding author. Mailing address: Department of Internal Medicine I, Division of Infectious Diseases and Chemotherapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Phone and fax: 431 40400 5200. E-mail: apostolos.georgopoulos{at}meduniwien.ac.at

{triangledown} Published ahead of print on 9 July 2007.

Antimicrobial Agents and Chemotherapy, September 2007, p. 3437-3439, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00130-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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