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Antimicrobial Agents and Chemotherapy, January 2008, p. 348-350, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00779-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Increased Macrolide Resistance of Mycoplasma pneumoniae in Pediatric Patients with Community-Acquired Pneumonia{triangledown}

Miyuki Morozumi,1 Satoshi Iwata,2 Keiko Hasegawa,1 Naoko Chiba,1 Reiko Takayanagi,3 Keita Matsubara,2 Eiichi Nakayama,1 Keisuke Sunakawa,4 Kimiko Ubukata,1* the Acute Respiratory Diseases Study Group

Laboratory of Molecular Epidemiology for Infectious Agents, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan,1 National Hospital Organization Tokyo Medical Center, Tokyo, Japan,2 Tohoku Rosai Hospital, Miyagi, Japan,3 Laboratory of Infectious Diseases, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan4

Received 18 June 2007/ Returned for modification 10 August 2007/ Accepted 12 October 2007

Among 380 Mycoplasma pneumoniae isolates from 3,678 pediatric patients with community-acquired pneumonia, 50 macrolide-resistant strains had an A2063G transition in domain V of the 23S rRNA, whereas 5 had an A2064G transition. These resistant strains increased rapidly from April 2002 to December 2006.

* Corresponding author. Mailing address: Laboratory of Molecular Epidemiology for Infectious Agents, Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minatoku, Tokyo 108-8641, Japan. Phone: 81-3-5791-6385. Fax: 81-3-5791-6386. E-mail: ubukatak{at}lisci.kitasato-u.ac.jp

{triangledown} Published ahead of print on 22 October 2007.

Antimicrobial Agents and Chemotherapy, January 2008, p. 348-350, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00779-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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  • Peuchant, O., Menard, A., Renaudin, H., Morozumi, M., Ubukata, K., Bebear, C. M., Pereyre, S. (2009). Increased macrolide resistance of Mycoplasma pneumoniae in France directly detected in clinical specimens by real-time PCR and melting curve analysis. J Antimicrob Chemother 64: 52-58 [Abstract] [Full Text]  
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