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Antimicrobial Agents and Chemotherapy, January 2008, p. 374-377, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00522-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis{triangledown}

Partha Palit and Nahid Ali*

Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, India

Received 20 April 2007/ Returned for modification 25 July 2007/ Accepted 8 October 2007

Amlodipine and lacidipine, conventional antihypertensive drugs, inhibited Leishmania donovani infection in vitro and in BALB/c mice when administered orally. These 1,4-dihydropyridine derivatives functioned through dose-dependent inhibition of oxygen consumption, triggering caspase 3-like activation-mediated programmed cell death of the parasites.

* Corresponding author. Mailing address: Indian Institute of Chemical Biology, Infectious Diseases and Immunology Division, 4 Raja S. C. Mullick Road, Kolkata 700032, India. Phone: 91-33-2473-3491. Fax: 91-33-2473-5197. E-mail: nali{at}iicb.res.in

{triangledown} Published ahead of print on 22 October 2007.

Antimicrobial Agents and Chemotherapy, January 2008, p. 374-377, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00522-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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