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Antimicrobial Agents and Chemotherapy, October 2008, p. 3786-3788, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00628-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Posaconazole Combined with Amphotericin B, an Effective Therapy for a Murine Disseminated Infection Caused by Rhizopus oryzae{triangledown}

M. Mar Rodríguez, Carolina Serena, Marçal Mariné, F. Javier Pastor, and Josep Guarro*

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain

Received 14 May 2008/ Returned for modification 25 June 2008/ Accepted 28 July 2008

In a murine model of disseminated zygomycosis, low doses of amphotericin B (0.3 mg/kg body weight/day) combined with posaconazole (40 mg/kg/day) prolonged survival and reduced tissue burden with respect to that of controls and that of both drugs administered alone. Results were similar to those obtained with amphotericin B given alone at 0.8 mg/kg/day.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain. Phone: 977-759359. Fax: 977-759322. E-mail: josep.guarro{at}urv.cat

{triangledown} Published ahead of print on 11 August 2008.

Antimicrobial Agents and Chemotherapy, October 2008, p. 3786-3788, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00628-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Rodriguez, M. M., Pastor, F. J., Calvo, E., Salas, V., Sutton, D. A., Guarro, J. (2009). Correlation of In Vitro Activity, Serum Levels, and In Vivo Efficacy of Posaconazole against Rhizopus microsporus in a Murine Disseminated Infection. Antimicrob. Agents Chemother. 53: 5022-5025 [Abstract] [Full Text]  
  • Rodriguez, M. M., Calvo, E., Marine, M., Pastor, F. J., Fernandez-Ballart, J., Guarro, J. (2009). Efficacy of Liposomal Amphotericin B Combined with Gamma Interferon or Granulocyte-Macrophage Colony-Stimulating Factor for Treatment of Systemic Zygomycosis in Mice. Antimicrob. Agents Chemother. 53: 3569-3571 [Abstract] [Full Text]  
  • Ibrahim, A. S., Gebremariam, T., Schwartz, J. A., Edwards, J. E. Jr., Spellberg, B. (2009). Posaconazole Mono- or Combination Therapy for Treatment of Murine Zygomycosis. Antimicrob. Agents Chemother. 53: 772-775 [Abstract] [Full Text]  


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