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Antimicrobial Agents and Chemotherapy, October 2008, p. 3801-3804, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00638-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Plasmid-Mediated Quinolone Resistance Pump QepA2 in an Escherichia coli Isolate from France {triangledown}

Vincent Cattoir,1,2 Laurent Poirel,1 and Patrice Nordmann1*

INSERM U914 Emerging Resistance to Antibiotics, Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K.-Bicêtre,1 Service de Bactériologie-Virologie-Hygiène, Hôpital Henri Mondor, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine de Créteil, Université Paris XII, Créteil, France2

Received 15 May 2008/ Returned for modification 22 June 2008/ Accepted 12 July 2008

One hundred twenty-one extended-spectrum β-lactamse-producing enterobacterial clinical isolates were screened for the qepA gene. A single CTX-M-15-positive Escherichia coli isolate (0.8%) that produced the putative pump QepA2 was identified. This qepA2 gene was located onto a 90-kb mobilizable plasmid that conferred reduced susceptibility to hydrophilic fluoroquinolones.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.aphp.fr

{triangledown} Published ahead of print on 21 July 2008.

Antimicrobial Agents and Chemotherapy, October 2008, p. 3801-3804, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00638-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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