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Antimicrobial Agents and Chemotherapy, October 2008, p. 3805-3809, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00579-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Population Structure Analysis of the Mycobacterium tuberculosis Beijing Family Indicates an Association between Certain Sublineages and Multidrug Resistance{triangledown} ,{dagger}

Tomotada Iwamoto,1* Shiomi Yoshida,2 Katsuhiro Suzuki,2 and Takayuki Wada3

Department of Microbiology, Kobe Institute of Health, 4-6 Minatojima-Nakamachi, Chuo-ku, Kobe 650-0046,1 Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone-cho, Sakai 591-8555,2 Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, 8-34 Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan3

Received 2 May 2008/ Returned for modification 12 June 2008/ Accepted 28 July 2008

Our population-based study of the Mycobacterium tuberculosis Beijing family examined the frequency of occurrence of each sublineage of this family, classified by using 10 synonymous single-nucleotide polymorphisms. The results revealed the overabundance of two evolutionary sublineages in a population of multidrug-resistant and extensively drug-resistant tuberculosis bacteria.

* Corresponding author. Mailing address: Department of Microbiology, Kobe Institute of Health, 4-6 Minatojima-Nakamachi, Chuo-ku, Kobe 650-0046, Japan. Phone: 81-78-302-6251. Fax: 81-78-302-0894. E-mail: kx2t-iwmt{at}asahi-net.or.jp

{triangledown} Published ahead of print on 11 August 2008.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, October 2008, p. 3805-3809, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00579-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Iwamoto, T., Fujiyama, R., Yoshida, S., Wada, T., Shirai, C., Kawakami, Y. (2009). Population Structure Dynamics of Mycobacterium tuberculosis Beijing Strains during Past Decades in Japan. J. Clin. Microbiol. 47: 3340-3343 [Abstract] [Full Text]  


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