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Antimicrobial Agents and Chemotherapy, November 2008, p. 4137-4140, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00196-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Metronidazole Lacks Antibacterial Activity in Guinea Pigs Infected with Mycobacterium tuberculosis{triangledown}

Donald R. Hoff,1 Megan L. Caraway,1 Elizabeth J. Brooks,1 Emily R. Driver,1 Gavin J. Ryan,1 Charles A. Peloquin,2 Ian M. Orme,1 Randall J. Basaraba,1 and Anne J. Lenaerts1*

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523,1 Infectious Diseases Pharmacokinetics Laboratory, National Jewish Medical and Research Center, Denver, Colorado2

Received 11 February 2008/ Returned for modification 13 March 2008/ Accepted 4 August 2008

Metronidazole, which is used for the treatment of infections caused by anaerobic organisms, was evaluated in Mycobacterium tuberculosis-infected guinea pigs. M. tuberculosis can adapt to hypoxia, which is present in the primary lesions of infected guinea pigs. Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation.

* Corresponding author. Mailing address: Department of Microbiology, Immunology and Pathology, Colorado State University, 200 West Lake Street, Fort Collins, CO 80523. Phone: (970) 491-3079. Fax: (970) 491-5125. E-mail: lenaerts{at}colostate.edu

{triangledown} Published ahead of print on 11 August 2008.

Antimicrobial Agents and Chemotherapy, November 2008, p. 4137-4140, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00196-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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