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Antimicrobial Agents and Chemotherapy, November 2008, p. 4159-4162, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.01633-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Plasmid-Mediated Quinolone Resistance Determinants qnrA, qnrB, and qnrS among Clinical Isolates of Enterobacteriaceae in a Korean Hospital{triangledown}

Migma Dorji Tamang, Sung Yong Seol, Jae-Young Oh, Hee Young Kang, Je Chul Lee, Yoo Chul Lee, Dong Taek Cho, and Jungmin Kim*

Department of Microbiology, Kyungpook National University School of Medicine, 101 Dongin-dong-2 ga, Jung-gu, Daegu 700-422, Republic of Korea

Received 19 December 2007/ Returned for modification 9 March 2008/ Accepted 13 August 2008

Screening of 368 consecutive nonreplicate clinical isolates of Enterobacteriaceae resistant to nalidixic acid and at least one extended-spectrum β-lactam revealed the presence of qnrA, qnrB, and qnrS determinants, and identified novel qnrB variants, in Citrobacter freundii isolates. This study also revealed, for the first time, the linkage of qnrB, armA, and extended-spectrum and/or AmpC-type β-lactamase genes on large conjugative plasmids.

* Corresponding author. Mailing address: Department of Microbiology, Kyungpook National University School of Medicine, 101 Dongin-dong-2 ga, Jung-gu, Daegu 700-422, Republic of Korea. Phone: 82-53-420-4845. Fax: 82-53427-5664. E-mail: minkim{at}knu.ac.kr

{triangledown} Published ahead of print on 25 August 2008.

Antimicrobial Agents and Chemotherapy, November 2008, p. 4159-4162, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.01633-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Strahilevitz, J., Jacoby, G. A., Hooper, D. C., Robicsek, A. (2009). Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat. Clin. Microbiol. Rev. 22: 664-689 [Abstract] [Full Text]  
  • Carattoli, A. (2009). Resistance Plasmid Families in Enterobacteriaceae. Antimicrob. Agents Chemother. 53: 2227-2238 [Full Text]  


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