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Antimicrobial Agents and Chemotherapy, November 2008, p. 4166-4171, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00245-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Characterization of TolC Efflux Pump Proteins from Pasteurella multocida{triangledown} ,{dagger}

Tamas Hatfaludi,1,3 Keith Al-Hasani,1,3 Michelle Dunstone,2,3 John Boyce,1,3 and Ben Adler1,3*

Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, VIC 3800, Australia,1 Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia,2 Department of Microbiology, Monash University, Clayton, VIC 3800, Australia3

Received 22 February 2008/ Returned for modification 26 March 2008/ Accepted 13 August 2008

Two TolC homologs, PM0527 and PM1980, were identified for Pasteurella multocida. A pm0527 mutant displayed increased susceptibility to a range of chemicals, including rifampin (512-fold) and acridine orange (128-fold). A pm1980 mutant showed increased susceptibility to rifampin, ceftazidime, and vancomycin.

* Corresponding author. Mailing address: Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, VIC 3800, Australia. Phone: 61 3 9905 4815. Fax: 61 3 9905 4811. E-mail: ben.adler{at}med.monash.edu.au

{triangledown} Published ahead of print on 25 August 2008.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, November 2008, p. 4166-4171, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00245-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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