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Antimicrobial Agents and Chemotherapy, November 2008, p. 4175-4177, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00420-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Rationale for Reading Fluconazole MICs at 24 Hours Rather than 48 Hours When Testing Candida spp. by the CLSI M27-A2 Standard Method{triangledown}

Luis Ostrosky-Zeichner,1* John H. Rex,1,2 Michael A. Pfaller,3 Daniel J. Diekema,3 Barbara D. Alexander,4 David Andes,5 Steven D. Brown,6 Vishnu Chaturvedi,7 Mahmoud A. Ghannoum,8 Cindy C. Knapp,9 Daniel J. Sheehan,10 and Thomas J. Walsh11

University of Texas Medical School at Houston, Houston, Texas,1 AstraZeneca, Macclesfield, Cheshire, United Kingdom,2 University of Iowa, Iowa City, Iowa,3 Duke University, Durham, North Carolina,4 University of Wisconsin, Madison, Wisconsin,5 The Clinical Microbiology Institute, Wilsonville, Oregon,6 New York State Department of Health, Albany, New York,7 Case Western Reserve University, Cleveland, Ohio,8 TREK Diagnostic Systems, Cleveland, Ohio,9 Pfizer Inc., New York, New York,10 National Cancer Institute, Bethesda, Maryland,11

Received 28 March 2008/ Returned for modification 2 July 2008/ Accepted 9 September 2008

We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata.

* Corresponding author. Mailing address: University of Texas Medical School at Houston, 6431 Fannin, MSB 2.112, Houston, TX 77030. Phone: (713) 500-6733. Fax: (713) 500-5495. E-mail: Luis.Ostrosky-Zeichner{at}uth.tmc.edu

{triangledown} Published ahead of print on 22 September 2008.

Antimicrobial Agents and Chemotherapy, November 2008, p. 4175-4177, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00420-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Espinel-Ingroff, A., Canton, E., Peman, J., Rinaldi, M. G., Fothergill, A. W. (2009). Comparison of 24-Hour and 48-Hour Voriconazole MICs as Determined by the Clinical and Laboratory Standards Institute Broth Microdilution Method (M27-A3 Document) in Three Laboratories: Results Obtained with 2,162 Clinical Isolates of Candida spp. and Other Yeasts. J. Clin. Microbiol. 47: 2766-2771 [Abstract] [Full Text]  
  • Arendrup, M. C., Cuenca-Estrella, M., Donnelly, J. P., Lass-Florl, C., Rodriguez-Tudela, J. L., Baddley, J. W., Ostrosky-Zeichner, L., Bhavnani, S. M., Andes, D. R. (2009). Association of Fluconazole Pharmacodynamics with Mortality in Patients with Candidemia. Antimicrob. Agents Chemother. 53: 2704-2706 [Full Text]  
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