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Antimicrobial Agents and Chemotherapy, November 2008, p. 4178-4180, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00715-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Efficacy of Single-Dose Liposomal Amphotericin B or Micafungin Prophylaxis in a Neutropenic Murine Model of Invasive Pulmonary Aspergillosis{triangledown}

Russell E. Lewis,1,2* Nathaniel D. Albert,1 and Dimitrios P. Kontoyiannis1,2

University of Houston College of Pharmacy,1 University of Texas M. D. Anderson Cancer Center, Houston, Texas2

Received 31 May 2008/ Returned for modification 29 July 2008/ Accepted 16 August 2008

In a neutropenic murine model of invasive pulmonary aspergillosis, prophylaxis with single doses of liposomal amphotericin B or micafungin at ≥5 mg/kg of body weight improved animal survival and suppressed the lung fungal burden for up to 7 days after infection, demonstrating the potential utility of infrequent dosing with these antifungals.

* Corresponding author. Mailing address: University of Houston College of Pharmacy, Texas Medical Center Campus, 1441 Moursund St., #424, Houston, TX 77030. Phone: (713) 795-8326. Fax: (713) 795-8383. E-mail: rlewis{at}uh.edu

{triangledown} Published ahead of print on 25 August 2008.

Antimicrobial Agents and Chemotherapy, November 2008, p. 4178-4180, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00715-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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  • Gubbins, P. O., Amsden, J. R., McConnell, S. A., Anaissie, E. J. (2009). Pharmacokinetics and Buccal Mucosal Concentrations of a 15 Milligram per Kilogram of Body Weight Total Dose of Liposomal Amphotericin B Administered as a Single Dose (15 mg/kg), Weekly Dose (7.5 mg/kg), or Daily Dose (1 mg/kg) in Peripheral Stem Cell Transplant Patients. Antimicrob. Agents Chemother. 53: 3664-3674 [Abstract] [Full Text]  


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