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Antimicrobial Agents and Chemotherapy, November 2008, p. 4198-4202, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00107-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Dominance of blaCTX-M within an Australian Extended-Spectrum β-Lactamase Gene Pool{triangledown}

Zhiyong Zong,1,3 Sally R. Partridge,1 Lee Thomas,2 and Jonathan R. Iredell1*

Centre for Infectious Diseases and Microbiology, University of Sydney,1 Institute for Clinical Pathology and Medical Research, Westmead Hospital, Sydney, New South Wales, Australia,2 Department of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China3

Received 25 January 2008/ Returned for modification 13 April 2008/ Accepted 13 August 2008

blaCTX-M genes, particularly blaCTX-M-15, are the dominant extended-spectrum β-lactamase (ESBL) genes among clinical isolates of Escherichia coli and Klebsiella pneumoniae in Sydney, Australia, where we also found one example of blaCTX-M-62, encoding a novel enzyme conferring ceftazidime resistance. ESBL genes were present in diverse community isolates and in a variety of associated conjugative plasmids.

* Corresponding author. Mailing address: CIDM, Level 3, ICPMR Building, Westmead Hospital, Westmead, NSW 2145, Australia. Phone: 61-2-9845-6255. Fax: 61-2-9891-5317. E-mail: jon.iredell{at}swahs.health.nsw.gov.au

{triangledown} Published ahead of print on 25 August 2008.

Antimicrobial Agents and Chemotherapy, November 2008, p. 4198-4202, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00107-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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