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Antimicrobial Agents and Chemotherapy, December 2008, p. 4483-4485, Vol. 52, No. 12
0066-4804/08/$08.00+0     doi:10.1128/AAC.00491-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

In Vitro Activities at pH 5.0 and pH 7.0 and In Vivo Efficacy of Flucytosine against Aspergillus fumigatus{triangledown}

Paul E. Verweij,1,2* Debbie T. A. Te Dorsthorst,1,2,3 Willem H. P. Janssen,1,2 Jacques F. G. M. Meis,3 and Johan W. Mouton3

Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands,1 Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands,2 Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital Nijmegen, Nijmegen, The Netherlands3

Received 15 April 2008/ Returned for modification 20 July 2008/ Accepted 4 September 2008

The antifungal agent flucytosine was found to be active in vitro against Aspergillus fumigatus isolates when the MIC was determined at pH 5.0 instead of pH 7.0. The in vitro MIC at pH 5.0 corresponded to the in vivo efficacy of flucytosine monotherapy in a murine model of invasive aspergillosis.

* Corresponding author. Mailing address: Department of Medical Microbiology, Radboud University Nijmegen Medical Center, P.O. Box 9101, Nijmegen 6500 HB, The Netherlands. Phone: 31-(0)24-3614356. Fax: 31-(0)24-3540216. E-mail: p.verweij{at}mmb.umcn.nl

{triangledown} Published ahead of print on 15 September 2008.

Antimicrobial Agents and Chemotherapy, December 2008, p. 4483-4485, Vol. 52, No. 12
0066-4804/08/$08.00+0     doi:10.1128/AAC.00491-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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