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Antimicrobial Agents and Chemotherapy, February 2008, p. 570-573, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01114-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Antimicrobial Activities of Tigecycline and Other Broad-Spectrum Antimicrobials Tested against Serine Carbapenemase- and Metallo-β-Lactamase-Producing Enterobacteriaceae: Report from the SENTRY Antimicrobial Surveillance Program{triangledown}

Mariana Castanheira,1* Hélio S. Sader,1,2 Lalitagauri M. Deshpande,1 Thomas R. Fritsche,1 and Ronald N. Jones1,3

JMI Laboratories, North Liberty, Iowa 52317,1 Universidade Federal de Sao Paulo, Sao Paulo, Brazil,2 Tufts University School of Medicine, Boston, Massachusetts 021113

Received 23 August 2007/ Returned for modification 23 October 2007/ Accepted 23 November 2007

A total of 104 carbapenemase (serine- and metallo-β-lactamase [MβL])-producing strains of the Enterobacteriaceae family collected from 2000 to 2005 in medical centers distributed worldwide were tested against tigecycline and 25 comparators by reference broth microdilution methods. The most frequent carbapenemase was KPC-2 or -3 (73 strains), followed by VIM-1 (14), IMP-1 (11), SME-2 (5), and NMC-A (1). All serine carbapenemases were detected in the United States, while MβL-producing strains were isolated in Europe. Carbapenemase-producing Enterobacteriaceae showed high rates of resistance to most antimicrobial agents tested. The rank order of in vitro activity against these strains was as follows: tigecycline (100.0% susceptible) > polymyxin B (88.1%) > amikacin (73.0%) > imipenem (37.5%). Tigecycline was very active (MIC90, 1 µg/ml) against this significant, contemporary collection of well-characterized strains and appears to be an excellent option compared to the polymyxins for treatment of infections caused by these multidrug-resistant Enterobacteriaceae.

* Corresponding author. Mailing address: 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317. Phone: (319) 665-3370. Fax: (319) 665-3371. E-mail: mariana-castanheira{at}jmilabs.com

{triangledown} Published ahead of print on 10 December 2007.

Antimicrobial Agents and Chemotherapy, February 2008, p. 570-573, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01114-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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