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Antimicrobial Agents and Chemotherapy, February 2008, p. 730-731, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01096-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Effect of Calcineurin Inhibitors on Posaconazole Blood Levels as Measured by the MVista Microbiological Assay{triangledown}

David Zhuang,1 Melinda Smedema,1 Ann LeMonte,1 Benita K. Book,2 Mark D. Pescovitz,2,3 and L. Joseph Wheat1*

MiraVista Diagnostics and MiraBella Technologies, Indianapolis, Indiana,1 Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana,2 Department of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, Indiana3

Received 21 August 2007/ Returned for modification 1 November 2007/ Accepted 10 November 2007

Calcineurin inhibitors may augment the effects of antifungal drugs in microbiological assays. We examined this interaction in a microbiological assay for posaconazole. No effect was observed. However, concurrent or recently discontinued treatment with other antifungal drugs caused false-positive results, emphasizing a limitation of microbiological assays for antifungal drug level measurement.

* Corresponding author. Mailing address: MiraVista Diagnostics, 4444 Decatur Blvd., Indianapolis, IN 46241. Phone: (317) 856-2681. Fax: (317) 856-3685. E-mail: jwheat{at}miravistalabs.com

{triangledown} Published ahead of print on 19 November 2007.

Antimicrobial Agents and Chemotherapy, February 2008, p. 730-731, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01096-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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