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Antimicrobial Agents and Chemotherapy, February 2008, p. 790-793, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.00928-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Analysis of the β-Tubulin Gene from Vittaforma corneae Suggests Benzimidazole Resistance{triangledown}

Caspar Franzen* and Bernd Salzberger

Department for Internal Medicine I, University of Regensburg, Regensburg, Germany

Received 17 July 2007/ Returned for modification 4 August 2007/ Accepted 17 November 2007

We amplified, cloned, and sequenced the β-tubulin gene of Vittaforma corneae, a microsporidium causing human infections. The β-tubulin gene sequence has a substitution at Glu198 (with glutamine), which is one of six amino acids reported to be associated with benzimidazole sensitivity. Benzimidazoles were assayed for antimicrosporidial activity and showed poor parasite inhibition.

* Corresponding author. Mailing address: Department for Internal Medicine I, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg. Germany. Phone and fax: 49-(0)941-944-7169. E-mail: Caspar.Franzen{at}Klinik.Uni-Regensburg.de

{triangledown} Published ahead of print on 3 December 2007.

Antimicrobial Agents and Chemotherapy, February 2008, p. 790-793, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.00928-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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