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Antimicrobial Agents and Chemotherapy, March 2008, p. 1173-1175, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01212-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Relationship between Antibiotic Use and Incidence of MexXY-OprM Overproducers among Clinical Isolates of Pseudomonas aeruginosa{triangledown}

Didier Hocquet,1* Arno Muller,2 Karine Blanc,1 Patrick Plésiat,1 Daniel Talon,3 Dominique Louis Monnet,2 and Xavier Bertrand3

National Reference Centre for Antibiotic Resistance—P. aeruginosa, Besançon, France,1 National Center for Antimicrobials and Infection Control, Copenhagen, Denmark,2 Department of Infection Control, Besançon Hospital, Besançon, France3

Received 13 September 2007/ Returned for modification 11 November 2007/ Accepted 23 December 2007

In a university hospital, time-series analysis revealed a significant relationship between antibiotic (aminoglycoside, fluoroquinolone, and cefepime) use and incidence of MexXY-OprM-overproducing Pseudomonas aeruginosa. In vitro experiments confirm that such mutants were readily selected from both PAO1 and clinical strains when grown in the presence of these antibiotics.

* Corresponding author. Mailing address: Laboratoire de Bactériologie, Centre National de Référence "Résistance aux antibiotiques: Pseudomonas aeruginosa," Hôpital Jean Minjoz, 25030 Besançon Cedex, France. Phone: (33) 3 81668286. Fax: (33) 3 81668914. E-mail: dhocquet{at}chu-besancon.fr

{triangledown} Published ahead of print on 7 January 2008.

Antimicrobial Agents and Chemotherapy, March 2008, p. 1173-1175, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01212-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Mima, T., Kohira, N., Li, Y., Sekiya, H., Ogawa, W., Kuroda, T., Tsuchiya, T. (2009). Gene cloning and characteristics of the RND-type multidrug efflux pump MuxABC-OpmB possessing two RND components in Pseudomonas aeruginosa. Microbiology 155: 3509-3517 [Abstract] [Full Text]  
  • Jeannot, K., Elsen, S., Kohler, T., Attree, I., van Delden, C., Plesiat, P. (2008). Resistance and Virulence of Pseudomonas aeruginosa Clinical Strains Overproducing the MexCD-OprJ Efflux Pump. Antimicrob. Agents Chemother. 52: 2455-2462 [Abstract] [Full Text]  


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