This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Polhemus, M. E.
Right arrow Articles by Heppner, D. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Polhemus, M. E.
Right arrow Articles by Heppner, D. G., Jr.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, April 2008, p. 1493-1495, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01367-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Malaria Treatment with Atovaquone-Proguanil in Malaria-Immune Adults: Implications for Malaria Intervention Trials and for Pre-Exposure Prophylaxis of Malaria{triangledown}

Mark E. Polhemus,1* Shon Remich,1 Bernhards Ogutu,2 John Waitumbi,2 Marc Lievens,3 W. Ripley Ballou,3 and D. Gray Heppner Jr.4

Walter Reed Project, United States Army Medical Research Unit, Kisumu, Kenya,1 Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya,2 GlaxoSmithKline Biologicals, Rixensart, Belgium,3 Walter Reed Army Institute of Research, Silver Spring, Maryland4

Received 23 October 2007/ Returned for modification 28 December 2007/ Accepted 10 January 2008

Eighty adults in areas of Kenya where malaria is holoendemic received presumptive treatment with atovaquone-proguanil and were followed closely. The time to the first Plasmodium falciparum parasitemia was 32 days. This prolonged prophylaxis period has implications for study design when used in malaria intervention trials and cautiously suggests clinical investigation of potential preexposure prophylaxis of malaria.

* Corresponding author. Mailing address: Unit 64109 (MRU), APO, AE 09831-4109. Phone: 254-733-616-550. E-mail: mpolhemus{at}wrp-ksm.org

{triangledown} Published ahead of print on 11 February 2008.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1493-1495, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01367-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»