This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Okazaki, A.
Right arrow Articles by Avison, M. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Okazaki, A.
Right arrow Articles by Avison, M. B.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, April 2008, p. 1525-1528, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01485-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Induction of L1 and L2 β-Lactamase Production in Stenotrophomonas maltophilia Is Dependent on an AmpR-Type Regulator{triangledown}

Aki Okazaki and Matthew B. Avison*

Bristol Centre for Antimicrobial Research and Evaluation, Department of Cellular & Molecular Medicine, University of Bristol, Bristol, United Kingdom

Received 15 November 2007/ Returned for modification 6 January 2008/ Accepted 12 January 2008

A divergently oriented ampR has been located upstream of blaL2 in Stenotrophomonas maltophilia. AmpR is necessary for L1 and L2 β-lactamase induction in response to β-lactam challenge, and activation of AmpR is sufficient to induce L1 and L2 production. L1 induction requires more activation of AmpR than does L2 induction.

* Corresponding author. Mailing address: Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom. Phone: 44 (0)1173312036. Fax: 44 (0)1179287897. E-mail: matthewb.avison{at}bris.ac.uk

{triangledown} Published ahead of print on 22 January 2008.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1525-1528, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01485-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Yang, T.-C., Huang, Y.-W., Hu, R.-M., Huang, S.-C., Lin, Y.-T. (2009). AmpDI Is Involved in Expression of the Chromosomal L1 and L2 {beta}-Lactamases of Stenotrophomonas maltophilia. Antimicrob. Agents Chemother. 53: 2902-2907 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»