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Antimicrobial Agents and Chemotherapy, April 2008, p. 1553-1555, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01280-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Potential Basis for Amphotericin B Resistance in Aspergillus terreus{triangledown}

Gerhard Blum,1 Susanne Perkhofer,1 Hubertus Haas,2 Markus Schrettl,2 Reinhard Würzner,1 Manfred P. Dierich,1 and Cornelia Lass-Flörl1*

Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria,1 Division of Molecular Biology, Innsbruck Biocenter, Innsbruck Medical University, Innsbruck, Austria2

Received 3 October 2007/ Returned for modification 29 November 2007/ Accepted 30 January 2008

This study investigated the basis for intrinsic amphotericin B (AMB) resistance in Aspergillus terreus. The ergosterol content, cell wall composition, and lipid peroxidation level had no influence on AMB resistance. The level of catalase production in A. terreus was significantly higher than that in A. fumigatus (P < 0.05). This higher-level production may contribute to AMB resistance in A. terreus since oxidative damage has been implicated in AMB action.

* Corresponding author. Mailing address: Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria. Phone: 43 0512 9003 70725. Fax: 43 0512 9003 73700. E-mail: cornelia.lass-floerl{at}i-med.ac.at

{triangledown} Published ahead of print on 11 February 2008.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1553-1555, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01280-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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