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Antimicrobial Agents and Chemotherapy, April 2008, p. 1559-1563, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01052-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Role of the AheABC Efflux Pump in Aeromonas hydrophila Intrinsic Multidrug Resistance{triangledown}

Mathieu Hernould, Séverine Gagné, Michel Fournier, Claudine Quentin, and Corinne Arpin*

CNRS UMR 5234, Université de Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France

Received 10 August 2007/ Returned for modification 10 October 2007/ Accepted 30 January 2008

Gene inactivation and complementation experiments showed that the tripartite AheABC efflux pump of Aeromonas hydrophila extruded at least 13 substrates, including nine antibiotics. The use of phenylalanine-arginine-β-naphthylamide (PAβN) revealed an additional system(s) contributing to intrinsic resistance. This is the first analysis of the role of multidrug efflux systems in Aeromonas spp.

* Corresponding author. Mailing address: CNRS UMR 5234, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France. Phone: 33-5-57-57-10-75. Fax: 33-5-56-90-90-72. E-mail: corinne.arpin{at}bacterio.u-bordeaux2.fr

{triangledown} Published ahead of print on 11 February 2008.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1559-1563, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01052-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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