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Antimicrobial Agents and Chemotherapy, April 2008, p. 1573-1576, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01488-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Comparison of Lipid Amphotericin B Preparations in Treating Murine Zygomycosis{triangledown}

Ashraf S. Ibrahim,1,2* Teclegiorgis Gebremariam,1 Mohamed I. Husseiny,1 David A. Stevens,3,4 Yue Fu,1,2 John E. Edwards Jr.,1,2 and Brad Spellberg1,2

Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California—Los Angeles Medical Center, Torrance, California,1 David Geffen School of Medicine, University of California—Los Angeles, Los Angeles, California,2 Division of Infectious Diseases, Santa Clara Valley Medical Center, San Jose, California,3 Stanford University School of Medicine, Stanford, California4

Received 15 November 2007/ Returned for modification 13 January 2008/ Accepted 20 January 2008

We compared the efficacies of liposomal amphotericin B (LAmB) and an amphotericin B lipid complex (ABLC) in diabetic ketoacidotic (DKA) or neutropenic mice with disseminated zygomycosis. ABLC was as effective as LAmB in neutropenic but not DKA mice. Low-dose ABLC was less effective than LAmB at reducing brain fungal burdens in both models.

* Corresponding author. Mailing address: Division of Infectious Diseases, Harbor-UCLA Medical Center, 1124 West Carson St., St. John's Cardiovascular Research Center, Torrance, CA 90502. Phone: (310) 222-6424. Fax: (310) 782-2016. E-mail: ibrahim{at}labiomed.org

{triangledown} Published ahead of print on 28 January 2008.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1573-1576, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01488-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Rodriguez, M. M., Calvo, E., Marine, M., Pastor, F. J., Fernandez-Ballart, J., Guarro, J. (2009). Efficacy of Liposomal Amphotericin B Combined with Gamma Interferon or Granulocyte-Macrophage Colony-Stimulating Factor for Treatment of Systemic Zygomycosis in Mice. Antimicrob. Agents Chemother. 53: 3569-3571 [Abstract] [Full Text]  


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