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Antimicrobial Agents and Chemotherapy, April 2008, p. 1577-1579, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01023-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Killing of Neisseria gonorrhoeae, Streptococcus agalactiae (Group B Streptococcus), Haemophilus ducreyi, and Vaginal Lactobacillus by 3-O-Octyl-sn-Glycerol{triangledown}

B. J. Moncla,1,2* K. Pryke,2 and Charles E. Isaacs3

Department of Obstetrics, Gynecology and Reproductive Sciences,1 Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania,2 New York State Institute for Basic Research in Developmental Disabilities, Department of Developmental Biochemistry, Staten Island, New York3

Received 3 August 2007/ Returned for modification 21 September 2007/ Accepted 22 January 2008

The microbicide candidate octylglycerol inactivates sexually transmitted bacterial pathogens at concentrations which spare normal vaginal flora (lactobacillus). Standard minimum microbicidal concentration assays and time-kill assays revealed the drug concentrations and times required for inactivation. Octylglycerol concentrations must exceed the binding capacity of any human serum albumin to be effective.

* Corresponding author. Mailing address: Room 520, Magee-Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA 15213-3180. Phone: (412) 641-6025. Fax: (412) 641-5290. E-mail: bjm4{at}pitt.edu

{triangledown} Published ahead of print on 28 January 2008.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1577-1579, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01023-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Skinner, M. C., Stamm, W. E., Lampe, M. L. (2009). Chlamydia trachomatis Laboratory Strains versus Recent Clinical Isolates: Implications for Routine Microbicide Testing. Antimicrob. Agents Chemother. 53: 1482-1489 [Abstract] [Full Text]  


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