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Antimicrobial Agents and Chemotherapy, May 2008, p. 1790-1793, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01440-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Multiclonal Outbreak of Klebsiella pneumoniae Producing Extended-Spectrum β-Lactamase CTX-M-2 and Novel Variant CTX-M-59 in a Neonatal Intensive Care Unit in Brazil{triangledown}

Doroti de Oliveira Garcia,1,2 Yohei Doi,2* Dora Szabo,3 Jennifer M. Adams-Haduch,2 Tânia M. I. Vaz,1 Daniela Leite,1 Maria Clara Padoveze,4 Maristela P. Freire,4 Fernanda P. Silveira,2 and David L. Paterson2,5,6

Instituto Adolfo Lutz, São Paulo, Brazil,1 Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania,2 Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary,3 Centro de Controle de Doencas, Divisão de Infecção Hospitalar, São Paulo, Brazil,4 University of Queensland, Brisbane, Australia,5 Queensland Health Pathology Services, Royal Brisbane and Women's Hospital, Brisbane, Australia6

Received 6 November 2007/ Returned for modification 30 December 2007/ Accepted 1 March 2008

An outbreak of cephalosporin-resistant Klebsiella pneumoniae occurred in a neonatal intensive care unit in São Paulo, Brazil. Of the 10 pulsotypes identified during the outbreak and follow-up periods, nine produced CTX-M-2 or its new variant CTX-M-59 and one produced SHV-5. blaCTX-M-2/59 genes were located on closely related plasmids that were transferable.

* Corresponding author. Mailing address: Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building, Suite 3A, 3601 Fifth Avenue, Pittsburgh, PA 15213. Phone: (412) 648-6401. Fax: (412) 648-6399. E-mail: doiy{at}dom.pitt.edu

{triangledown} Published ahead of print on 17 March 2008.

Antimicrobial Agents and Chemotherapy, May 2008, p. 1790-1793, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01440-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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