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Antimicrobial Agents and Chemotherapy, May 2008, p. 1850-1851, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01139-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Activity of Daptomycin against Listeria monocytogenes Isolates from Cerebrospinal Fluid{triangledown}

Lodewijk Spanjaard* and Christina M. J. E. Vandenbroucke-Grauls{dagger}

Netherlands Reference Laboratory for Bacterial Meningitis, Department of Medical Microbiology, and Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

Received 29 August 2007/ Returned for modification 20 November 2007/ Accepted 13 February 2008

We tested the activity of daptomycin against 76 Listeria monocytogenes isolates from cerebrospinal fluid by broth dilution and Etest methods. For the broth dilution method, the MIC range was 1.0 to 8.0 and the MIC at which 90% of the isolates tested were inhibited (MIC90) was 4.0 mg/liter. For the Etest method, the MIC range was 1.0 to 4.0 and the MIC90 was 4.0 mg/liter. Presently, daptomycin cannot be recommended for the treatment of L. monocytogenes meningitis.


* Corresponding author. Mailing address: Department of Medical Microbiology, L1-243, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands. Phone: 31 20 566 3026. Fax: 31 20 566 9745. E-mail: L.Spanjaard{at}amc.uva.nl

{triangledown} Published ahead of print on 19 February 2008.

{dagger} Present address: Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands.


Antimicrobial Agents and Chemotherapy, May 2008, p. 1850-1851, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01139-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.




This article has been cited by other articles:

  • Warren, R. E. (2008). Daptomycin in endocarditis and bacteraemia: a British perspective. J Antimicrob Chemother 62: iii25-iii33 [Abstract] [Full Text]