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Antimicrobial Agents and Chemotherapy, May 2008, p. 1871-1872, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01370-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Efficacy of SPK-843, a Novel Polyene Antifungal, in a Murine Model of Systemic Cryptococcosis{triangledown}

Hiroshi Kakeya,1* Yoshitsugu Miyazaki,2 Hisato Senda,3 Tsutomu Kobayashi,1 Masafumi Seki,1 Koichi Izumikawa,1 Yoshihiro Yamamoto,1 Kazunori Yanagihara,1 Takayoshi Tashiro,1 and Shigeru Kohno1

Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan,1 Department of Bioactive Molecules, National Institute of Infectious Disease, Tokyo, Japan,2 Kaken Pharmaceutical Co., Ltd., Kyoto, Japan3

Received 24 October 2007/ Returned for modification 20 November 2007/ Accepted 16 February 2008

SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Phone: 81-95-819-7273. Fax: 81-95-849-7285. E-mail: kakeya{at}nagasaki-u.ac.jp

{triangledown} Published ahead of print on 25 February 2008.

Antimicrobial Agents and Chemotherapy, May 2008, p. 1871-1872, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01370-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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