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Antimicrobial Agents and Chemotherapy, May 2008, p. 1888-1890, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.00035-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Emergence of Fluoroquinolone Resistance in Group B Streptococcal Isolates in Taiwan{triangledown}

Hsiu-Mei Wu,1 Rajendra Prasad Janapatla,1 Yueh-Ren Ho,2,4 Kuei-Hsiang Hung,4 Chi-Wen Wu,1 Jing-Jou Yan,3 and Jiunn-Jong Wu1,4*

Departments of Medical Laboratory Science and Biotechnology,1 Biochemistry and Molecular Biology,2 Pathology,3 Institute of Basic Medical Science, College of Medicine, National Cheng Kung University, Tainan, Taiwan4

Received 9 January 2008/ Returned for modification 13 February 2008/ Accepted 18 February 2008

Of 1,994 group B streptococcal isolates collected, 26 (1.3%) of the isolates were resistant to levofloxacin, and cross-resistance to other fluoroquinolones was observed. The emergence and prevalence of high-level fluoroquinolone resistance in genetically unrelated isolates were linked to the presence of gyrA, parC, and parE triple mutations in each isolate.

* Corresponding author. Mailing address: Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng-Kung University, No. 1 University Rd., Tainan, Taiwan 70101. Phone: 886-6-2353535, ext. 5775. Fax: 886-6-2363956. E-mail: jjwu{at}mail.ncku.edu.tw

{triangledown} Published ahead of print on 25 February 2008.

Antimicrobial Agents and Chemotherapy, May 2008, p. 1888-1890, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.00035-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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