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Antimicrobial Agents and Chemotherapy, June 2008, p. 2253-2255, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.01536-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Interactions of DB75, a Novel Antimalarial Agent, with Other Antimalarial Drugs In Vitro{triangledown}

Anne E. Purfield, Richard R. Tidwell, and Steven R. Meshnick*

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599-7435

Received 28 November 2007/ Returned for modification 20 January 2008/ Accepted 11 March 2008

Pafuramidine is a novel orally active antimalarial. To identify a combination partner, we measured the in vitro antimalarial activities of the active metabolite, DB75, with amodiaquine, artemisinin, atovaquone, azithromycin, chloroquine, clindamycin, mefloquine, piperaquine, pyronaridine, tafenoquine, and tetracycline. None of the drugs tested demonstrated antagonistic or synergistic activity in combination with pafuramidine.

* Corresponding author. Mailing address: Department of Epidemiology, CB 7435, University of North Carolina, Chapel Hill, NC 27599-7435. Phone: (919) 966-7414. Fax: (919) 966-2089. E-mail: meshnick{at}unc.edu

{triangledown} Published ahead of print on 24 March 2008.

Antimicrobial Agents and Chemotherapy, June 2008, p. 2253-2255, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.01536-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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