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Antimicrobial Agents and Chemotherapy, June 2008, p. 2260-2262, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.01270-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Mechanisms of Macrolide Resistance among Streptococcus pneumoniae Isolates from Russia{triangledown}

Ralf R. Reinert,1 Olga Y. Filimonova,2 Adnan Al-Lahham,3 Svetlana A. Grudinina,2 Elena N. Ilina,4 Linda M. Weigel,5 and Sergey V. Sidorenko2*

Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital (RWTH), Aachen, Germany,1 National Research Center of Antibiotics, Moscow, Russia,2 German Jordanian University, School of Applied Medical Sciences, Amman, Jordan,3 Institute of Physico-Chemical Medicine, Moscow, Russia,4 Centers for Disease Control and Prevention, Atlanta, Georgia5

Received 1 October 2007/ Returned for modification 1 November 2007/ Accepted 24 March 2008

Among 76 macrolide-nonsusceptible Streptococcus pneumoniae isolates collected between 2003 and 2005 from Central Russia, the resistance mechanisms detected in the isolates included erm(B) alone (50%), mef alone [mef(E), mef(I), or a different mef subclass; 19.7%], or both erm(B) and mef(E) (30.3%). Isolates with dual resistance genes [erm(B) and mef(E)] belonged to clonal complex CC81 or CC271.

* Corresponding author. Mailing address: National Research Center of Antibiotics, 3a Nagatinskaya Str., Moscow 117105, Russia. Phone: 7 499 6117619. Fax: 7 499 6114238. E-mail: sidorserg{at}yandex.ru

{triangledown} Published ahead of print on 31 March 2008.

Antimicrobial Agents and Chemotherapy, June 2008, p. 2260-2262, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.01270-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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