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Antimicrobial Agents and Chemotherapy, July 2008, p. 2636-2638, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.00492-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Posaconazole Enhances the Activity of Amphotericin B against Hyphae of Zygomycetes In Vitro{triangledown}

Susanne Perkhofer,1* Maria Locher,1 Manuel Cuenca-Estrella,2 Reinhard Rüchel,3 Reinhard Würzner,1 Manfred P. Dierich,1 and Cornelia Lass-Flörl1

Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria,1 Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain,2 Department of Medical Microbiology and National Reference Center for Systemic Mycoses, University Hospital of Göttingen, Göttingen, Germany3

Received 15 April 2008/ Returned for modification 20 April 2008/ Accepted 25 April 2008

The in vitro activity of posaconazole plus amphotericin B against conidia and hyphae of 30 clinical zygomycetes was investigated. The combination of posaconazole with amphotericin B was found to be significantly more synergistic (40%) against hyphae (P < 0.05) than against conidia (10%). Antagonism was not observed.

* Corresponding author. Mailing address: Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz-Pregl Str. 3, A-6020 Innsbruck, Austria. Phone: 43 512 9003 70729. Fax: 43 512 9003 73700. E-mail: Susanne.Perkhofer{at}i-med.ac.at

{triangledown} Published ahead of print on 5 May 2008.

Antimicrobial Agents and Chemotherapy, July 2008, p. 2636-2638, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.00492-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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