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Antimicrobial Agents and Chemotherapy, July 2008, p. 2639-2643, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.00310-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Prevalence of Serotype 19A Streptococcus pneumoniae among Isolates from U.S. Children in 2005-2006 and Activity of Faropenem{triangledown}

Ian A. Critchley,1* Michael R. Jacobs,2 Steven D. Brown,3 Maria M. Traczewski,3 Glenn S. Tillotson,4 and Nebojsa Janjic1

Replidyne, Inc., Louisville, Colorado 80027,1 Department of Pathology, Case Western Reserve University, and University Hospitals, Case Medical Center, Cleveland, Ohio 44106,2 Clinical Microbiology Institute, Wilsonville, Oregon 97070,3 Replidyne, Inc., Milford, Connecticut 064604

Received 6 March 2008/ Returned for modification 3 April 2008/ Accepted 18 April 2008

Of 393 isolates of Streptococcus pneumoniae from U.S. children collected in 2005-2006, nonvaccine serotypes accounted for 89.1%, with serotype 19A the most prevalent, representing 30.5% of all isolates. The MIC90 of faropenem against serotype 19A isolates was 1 µg/ml, compared to ≥8 µg/ml against amoxicillin/clavulanate, cefdinir, cefuroxime axetil, and azithromycin.

* Corresponding author. Mailing address: Replidyne Inc., 1450 Infinite Drive, Louisville, CO 80027. Phone: (303) 996-5531. Fax: (303) 996 5599. E-mail: icritchley{at}replidyne.com

{triangledown} Published ahead of print on 28 April 2008.

Antimicrobial Agents and Chemotherapy, July 2008, p. 2639-2643, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.00310-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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