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Antimicrobial Agents and Chemotherapy, July 2008, p. 2644-2646, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.01618-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Impact of Mycophenolic Acid on the Functionality of Human Polymorphonuclear Neutrophils and Dendritic Cells during Interaction with Aspergillus fumigatus{triangledown}

Markus Mezger,1,{dagger} Iwona Wozniok,1,{dagger} Christian Blockhaus,1 Oliver Kurzai,2 Holger Hebart,3 Hermann Einsele,1 and Juergen Loeffler1*

Medizinische Klinik & Poliklinik II,1 Institut für Hygiene und Mikrobiologie, Universität Würzburg, 97070 Würzburg,2 Staufer-Klinik Schwäbisch Gmünd, Innere Medizin, 73557 Mutlangen, Germany3

Received 18 December 2007/ Returned for modification 15 January 2008/ Accepted 11 April 2008

Mycophenolic acid (MPA) is used clinically to prevent graft rejection but may increase the risk of fungal infection. We observed that MPA enhanced the Aspergillus fumigatus-induced oxidative burst of polymorphonuclear neutrophils, but without a corresponding increase in fungal killing. Furthermore, MPA inhibited the proinflammatory cytokine response and maturation of dendritic cells.

* Corresponding author. Mailing address: Medizinische Klinik II, Josef-Schneider-Str. 2, 97070 Würzburg, Germany. Phone: 49 931 201 36412. Fax: 49 931 201 36409. E-mail: loeffler_j{at}klinik.uni-wuerzburg.de

{triangledown} Published ahead of print on 21 April 2008.

{dagger} M.M. and I.W. contributed equally to this work.

Antimicrobial Agents and Chemotherapy, July 2008, p. 2644-2646, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.01618-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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