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Antimicrobial Agents and Chemotherapy, August 2008, p. 2933-2936, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.00456-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Relationship between Various Definitions of Prior Antibiotic Exposure and Piperacillin-Tazobactam Resistance among Patients with Respiratory Tract Infections Caused by Pseudomonas aeruginosa{triangledown}

Nimish Patel,1 Louise-Anne McNutt,2 and Thomas P. Lodise1,3*

Albany College of Pharmacy, Pharmacy Practice Department, Albany, New York,1 Department of Epidemiology, School of Public Health, University at Albany, State University of New York, Albany, New York,2 Ordway Research Institute, Albany, New York3

Received 6 April 2008/ Returned for modification 5 May 2008/ Accepted 28 May 2008

Contemporary literature lacks a definition of prior antibiotic exposure which captures all patients at risk of developing piperacillin-tazobactam-resistant Pseudomonas aeruginosa (PTR-PA). The results indicated that individual antibiotics that are associated with PTR-PA differ depending on the definition of prior antibiotic exposure utilized. When the specific antibiotic used was replaced by the number of prior exposures, the number of exposures was the only variable associated with an increased risk of antibiotic resistance at each time threshold.

* Corresponding author. Mailing address: Albany College of Pharmacy, Department of Pharmacy Practice, 106 New Scotland Avenue, Albany, NY 12208-3492. Phone: (518) 445-7292. Fax: (518) 694-7062. E-mail: lodiset{at}acp.edu

{triangledown} Published ahead of print on 2 June 2008.

Antimicrobial Agents and Chemotherapy, August 2008, p. 2933-2936, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.00456-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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