This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hoshi, S.
Right arrow Articles by Hiramatsu, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hoshi, S.
Right arrow Articles by Hiramatsu, K.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, August 2008, p. 2970-2973, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.01466-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Postantibiotic Effects and Bactericidal Activities of Levofloxacin and Gatifloxacin at Concentrations Simulating Those of Topical Ophthalmic Administration against Fluoroquinolone-Resistant and Fluoroquinolone-Sensitive Methicillin-Resistant Staphylococcus aureus Strains{triangledown}

Saichi Hoshi,1,2 Ken Kikuchi,1* Takashi Sasaki,1 Chie Sotozono,2 Shigeru Kinoshita,2 and Keiichi Hiramatsu1

Department of Infection Control Science, Faculty of Medicine, Juntendo University, Tokyo 113-8421, Japan,1 Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan2

Received 13 November 2007/ Returned for modification 23 February 2008/ Accepted 9 May 2008

The bactericidal activities and postantibiotic effects (PAEs) of levofloxacin and gatifloxacin at concentrations corresponding to those in antibiotic eye drops against methicillin-resistant Staphylococcus aureus strains were determined. Levofloxacin and gatifloxacin at concentrations simulating those in eye drops showed lower bactericidal activities and shorter PAEs against fluoroquinolone-resistant strains than against fluoroquinolone-sensitive strains.

* Corresponding author. Mailing address: Department of Infection Control Science, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. Phone: 81-3-3813-3111, ext. 3822. Fax: 81-3-3816-2782. E-mail: kikuti{at}med.juntendo.ac.jp

{triangledown} Published ahead of print on 19 May 2008.

Antimicrobial Agents and Chemotherapy, August 2008, p. 2970-2973, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.01466-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»