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Antimicrobial Agents and Chemotherapy, September 2008, p. 3394-3397, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.01599-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Effects of Subinhibitory Concentrations of Antibiotics on SOS and DNA Repair Gene Expression in Staphylococcus aureus{triangledown} ,{dagger}

Lili Rosana Mesak,* Vivian Miao, and Julian Davies

Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada

Received 11 December 2007/ Returned for modification 15 January 2008/ Accepted 21 June 2008

Reporter clones of Staphylococcus aureus with different SOS response- and DNA repair-associated promoter-lux gene fusion constructs were constructed to study the effects of sub-MICs of antibiotics on the transcription of the SOS and methyl mismatch repair (MMR) genes. Fluoroquinolones (FQs) upmodulated both the SOS and the MMR genes. The patterns of antibiotic-induced transcriptional modulation were altered in FQ-resistant mutants.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, 2350 Health Science Mall, Vancouver, BC V6T 1Z3, Canada. Phone: (604) 822-9308. Fax: (604) 822-6041. E-mail: mesak{at}interchange.ubc.ca

{triangledown} Published ahead of print on 30 June 2008.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, September 2008, p. 3394-3397, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.01599-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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