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Antimicrobial Agents and Chemotherapy, September 2008, p. 3408-3410, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00501-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Recombination and Selection Can Remove blaTEM Alleles from Bacterial Populations {triangledown}

Joanna E. Mroczkowska and Miriam Barlow*

School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, California

Received 16 April 2008/ Returned for modification 5 June 2008/ Accepted 3 July 2008

We passaged cells expressing TEM-1 and TEM-12 from a single plasmid through either ampicillin or ceftazidime. We found that the combined effects of recombination and selection removed the blaTEM-1 allele from the bacterial population when it was passaged through ceftazidime or the blaTEM-12 allele when cultures were passaged through ampicillin.

* Corresponding author. Mailing address: School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343. Phone: (209) 228-4174. Fax: (209) 228-4060. E-mail: mbarlow{at}ucmerced.edu

{triangledown} Published ahead of print on 14 July 2008.

Antimicrobial Agents and Chemotherapy, September 2008, p. 3408-3410, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00501-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Barlow, M., Fatollahi, J., Salverda, M. (2009). Evidence for recombination among the alleles encoding TEM and SHV {beta}-lactamases. J Antimicrob Chemother 63: 256-259 [Abstract] [Full Text]  


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