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Antimicrobial Agents and Chemotherapy, September 2008, p. 3411-3413, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.01656-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Reduced Biocide Susceptibility in Candida albicans Biofilms{triangledown}

Jeniel E. Nett,1,3 Kristie M. Guite,1 Alex Ringeisen,2 Kathleen A. Holoyda,2 and David R. Andes1,2,3*

Departments of Medicine,1 Medical Microbiology and Immunology,2 Cellular and Molecular Biology, University of Wisconsin, Madison, Wisconsin 537923

Received 21 December 2007/ Returned for modification 25 March 2008/ Accepted 12 June 2008

Candida biofilm formation is common during infection and environmental growth. We tested the impacts of three biocides (ethanol [EtOH], H2O2, and sodium dodecyl sulfate) on Candida albicans, C. parapsilosis, and C. glabrata biofilms. Higher concentrations of the biocides were required for efficacy against biofilms than for efficacy against planktonic controls. A combination study with two biocides (EtOH and H2O2) and fluconazole demonstrated that the combination had enhanced efficacy.

* Corresponding author. Mailing address: Department of Cellular and Molecular Biology, Room H4/572, Clinical Sciences Center, 600 Highland Ave., University of Wisconsin, Madison, WI 53792. Phone: (608) 263-1545. Fax: (608) 263-4464. E-mail: dra{at}medicine.wisc.edu

{triangledown} Published ahead of print on 23 June 2008.

Antimicrobial Agents and Chemotherapy, September 2008, p. 3411-3413, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.01656-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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