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Antimicrobial Agents and Chemotherapy, September 2008, p. 3451-3453, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00562-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Antimalarial Activity of a New Stilbene Glycoside from Parthenocissus tricuspidata in Mice{triangledown}

Won-Hwan Park,1 Sung-Jae Lee,2 and Hyung-In Moon3*

Department of Diagnostics and Cardiovascular Medical Research Center, College of Korean Medicine, Dongguk University, Gyeong-Ju 780-714, South Korea,1 Department of Integrative Medicine, College of Medicine, Korea University, Anam-dong 5ga, Seongbuk-gu, Seoul 136-705, South Korea,2 Department of Neurology and Inam Neuro Science Research Center, Wonkwang University Sanbon Medical Center, Kyunggi-Do 435-040, South Korea3

Received 30 April 2008/ Returned for modification 19 June 2008/ Accepted 30 June 2008

A novel stilbene glycoside [piceid-(1->6)-β-D-glucopyranoside; PBG] from Parthenocissus tricuspidata was tested in vivo against Plasmodium berghei. PBG exhibited significant blood schizontocidal activity in a 4-day early infection, a repository evaluation, and an established infection, with a significant mean survival time comparable to that obtained with the standard drug, chloroquine (5 mg·kg–1·day–1).

* Corresponding author. Mailing address: Inam Neuro Science Research Center, Department of Neurology, Wonkwang University Sanbon Medical Center, Sanbon-dong, Gunpo-City, Kyunggi-Do 435-040, South Korea. Phone and fax: (82)-313902414. E-mail: himoon{at}wonkwang.ac.kr

{triangledown} Published ahead of print on 14 July 2008.

Antimicrobial Agents and Chemotherapy, September 2008, p. 3451-3453, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00562-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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