This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Louie, T. J.
Right arrow Articles by Mah, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Louie, T. J.
Right arrow Articles by Mah, M.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, January 2009, p. 261-263, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.01443-07
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

OPT-80 Eliminates Clostridium difficile and Is Sparing of Bacteroides Species during Treatment of C. difficile Infection{triangledown}

Thomas J. Louie,* Judy Emery, Walter Krulicki, Brendan Byrne, and Manuel Mah

Division of Infectious Diseases, Departments of Medicine and Microbiology Infectious Diseases, University of Calgary, Calgary, Alberta, Canada, and Infection Prevention & Control Program, Calgary Health Region, Calgary, Alberta, Canada

Received 6 November 2007/ Returned for modification 26 March 2008/ Accepted 17 October 2008

During a 10-day treatment for Clostridium difficile infection, OPT-80 and vancomycin were comparably effective in reducing C. difficile counts. Bacteroides fragilis group counts appeared unaffected with increasing dosages of OPT-80, whereas vancomycin was markedly suppressive. Retention of components of the normal microflora might lower the risk of recurrent disease.

* Corresponding author. Mailing address: Infection Prevention & Control, AGW-5, Foothills Medical Center, 1403 29th St. N.W., Calgary, Alberta T2N 2T9, Canada. Phone: (403) 944-4766. Fax: (403) 944-2484. E-mail: thomas.louie{at}calgaryhealthregion.ca

{triangledown} Published ahead of print on 27 October 2008.

Antimicrobial Agents and Chemotherapy, January 2009, p. 261-263, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.01443-07
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Williams, O. M., Spencer, R. C. (2009). The management of Clostridium difficile infection. Br Med Bull 91: 87-110 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»