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Antimicrobial Agents and Chemotherapy, January 2009, p. 264-266, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.00258-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Optimized Elution of Daptomycin from Polymethylmethacrylate Beads{triangledown}

Brian D. Weiss,1 Elizabeth C. Weiss,1 Warren O. Haggard,3 Richard P. Evans,2 Sandra G. McLaren,2 and Mark S. Smeltzer1,2*

Department of Microbiology and Immunology,1 Department of Orthopedic Surgery and Center for Orthopedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205,2 Department of Biomedical Engineering, University of Memphis, Memphis, Tennessee 381523

Received 25 February 2008/ Returned for modification 26 May 2008/ Accepted 18 October 2008

We demonstrate that xylitol can be added to polymethylmethacrylate (PMMA) bone cement to enhance the elution of daptomycin in terms of both the peak and sustained release of antibiotic. We also demonstrate that a PMMA-xylitol formulation optimized for daptomycin can be used to enhance the elution of both vancomycin and gentamicin.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W. Markham, Mail Slot 511, Little Rock, AR 72205. Phone: (501) 686-7958. Fax: (501) 686-5359. E-mail: smeltzermarks{at}uams.edu

{triangledown} Published ahead of print on 27 October 2008.

Antimicrobial Agents and Chemotherapy, January 2009, p. 264-266, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.00258-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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