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Antimicrobial Agents and Chemotherapy, January 2009, p. 267-270, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.00402-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Genotypic versus Phenotypic Characterization, with Respect to β-Lactam Susceptibility, of Haemophilus influenzae Isolates Exhibiting Decreased Susceptibility to β-Lactam Resistance Markers{triangledown}

David Sevillano,1 María-José Giménez,1 Emilia Cercenado,2 Fabio Cafini,1 Amadeo Gené,3 Luis Alou,1 Francesc Marco,4 Luis Martínez-Martínez,5 Pilar Coronel,6 and Lorenzo Aguilar1*

Microbiology Department, School of Medicine, Univ. Complutense, Madrid, Spain,1 Microbiology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain,2 Microbiology Department, Hospital San Joan de Deu, Barcelona, Spain,3 Microbiology Department, Hospital Clinic, Barcelona, Spain,4 Microbiology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain,5 Scientific Department, Tedec-Meiji Farma S.A., Madrid, Spain6

Received 25 March 2008/ Returned for modification 24 June 2008/ Accepted 17 October 2008

Among 165 Spanish Haemophilus influenzae isolates with mutations in the ftsI gene (ftsI+) (2005 to 2007), 73% were β-lactamase negative and 26.7% were positive. The proportion of β-lactamase-negative isolates to β-lactamase-positive isolates was 2:1 to 4:1 in general, versus 1:3 in pediatric hospitals. Among 44 β-lactamase-positive strains, 8 strains produced ROB-1 (5 from the pediatric hospital). β-Lactamase-positive ftsI+ strains were phylogenetically closer than were β-lactamase-negative strains.

* Corresponding author. Mailing address: Microbiology Department, School of Medicine, Universidad Complutense, Avda. Complutense s/n, 28040 Madrid, Spain. Phone: 34-91-3941505. Fax: 34-91-3941511. E-mail: laguilar{at}med.ucm.es

{triangledown} Published ahead of print on 27 October 2008.

Antimicrobial Agents and Chemotherapy, January 2009, p. 267-270, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.00402-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gonzalez, N., Aguilar, L., Alou, L., Gimenez, M.-J., Sevillano, D., Torrico, M., Cafini, F., Coronel, P., Prieto, J. (2009). Influence of different resistance traits on the competitive growth of Haemophilus influenzae in antibiotic-free medium and selection of resistant populations by different {beta}-lactams: an in vitro pharmacodynamic approach. J Antimicrob Chemother 63: 1215-1222 [Abstract] [Full Text]  


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