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Antimicrobial Agents and Chemotherapy, January 2009, p. 295-297, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.01023-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Efficacy of Ciprofloxacin and Moxifloxacin against Nocardia brasiliensis In Vitro and in an Experimental Model of Actinomycetoma in BALB/c Mice{triangledown}

Brenda Edith Chacon-Moreno,1 Oliverio Welsh,1 Norma Cavazos-Rocha,2 Maria de la Luz Salazar-Cavazos,2 Hector Gerardo Garza-Lozano,3 Salvador Said-Fernandez,3 Jorge Ocampo-Candiani,1 and Lucio Vera-Cabrera1*

Servicio de Dermatología, Hospital Universitario José E. González, Monterrey, NL,1 Departamento de Química Analítica, Facultad de Medicina, UANL, Monterrey, NL,2 Centro de Investigación Biomédica del Noreste, IMSS, Monterrey, NL, México3

Received 31 July 2008/ Returned for modification 2 September 2008/ Accepted 7 October 2008

The efficacy of ciprofloxacin and moxifloxacin against Nocardia brasiliensis was evaluated by applying 25 mg of each drug/kg subcutaneously every 8 h in BALB/c mice infected with N. brasiliensis. A statistically significant difference was observed only with moxifloxacin. A moxifloxacin-trimethoprim-sulfamethoxazole combination was as active as when each compound was used alone.

* Corresponding author. Mailing address: Servicio de Dermatología, Hospital Universitario José E. González, Madero y Gonzalitos, Col. Mitras Centro, Monterrey, NL, CP 64460, Mexico. Phone: (5281) 83480383. Fax: (5281) 83484407. E-mail: luvera_99{at}yahoo.com

{triangledown} Published ahead of print on 13 October 2008.

Antimicrobial Agents and Chemotherapy, January 2009, p. 295-297, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.01023-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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