This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ibrahim, A. S.
Right arrow Articles by Spellberg, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ibrahim, A. S.
Right arrow Articles by Spellberg, B.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, February 2009, p. 772-775, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.01124-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Posaconazole Mono- or Combination Therapy for Treatment of Murine Zygomycosis{triangledown}

Ashraf S. Ibrahim,1,2* Teclegiorgis Gebremariam,1 Julie A. Schwartz,3 John E. Edwards Jr.,1,2 and Brad Spellberg1,2

Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor—University of California Los Angeles Medical Center, Torrance, California,1 David Geffen School of Medicine at UCLA, Los Angeles, California,2 Charles River Laboratories, Davis, California3

Received 21 August 2008/ Returned for modification 28 September 2008/ Accepted 9 October 2008

We compared the efficacy of combination posaconazole-liposomal amphotericin B (LAmB) therapy to monotherapy with either drug in diabetic ketoacidotic or neutropenic mice with disseminated zygomycosis caused by Rhizopus oryzae. Combination therapy was no better than LAmB alone, and posaconazole monotherapy did not improve survival or reduce fungal burden versus placebo.

* Corresponding author. Mailing address: Division of Infectious Diseases, Harbor—UCLA Medical Center, 1124 West Carson St., St. John's Cardiovascular Research Center, Torrance, CA 90502. Phone: (310) 222-6424. Fax: (310) 782-2016. E-mail: ibrahim{at}labiomed.org

{triangledown} Published ahead of print on 20 October 2008.

Antimicrobial Agents and Chemotherapy, February 2009, p. 772-775, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.01124-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Rodriguez, M. M., Pastor, F. J., Calvo, E., Salas, V., Sutton, D. A., Guarro, J. (2009). Correlation of In Vitro Activity, Serum Levels, and In Vivo Efficacy of Posaconazole against Rhizopus microsporus in a Murine Disseminated Infection. Antimicrob. Agents Chemother. 53: 5022-5025 [Abstract] [Full Text]  
  • Rodriguez, M. M., Calvo, E., Marine, M., Pastor, F. J., Fernandez-Ballart, J., Guarro, J. (2009). Efficacy of Liposomal Amphotericin B Combined with Gamma Interferon or Granulocyte-Macrophage Colony-Stimulating Factor for Treatment of Systemic Zygomycosis in Mice. Antimicrob. Agents Chemother. 53: 3569-3571 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»