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Antimicrobial Agents and Chemotherapy, February 2009, p. 788-790, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.01131-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antifungal Activity of Caspofungin in Combination with Amphotericin B against Candida glabrata: Comparison of Disk Diffusion, Etest, and Time-Kill Methods{triangledown}

Nuri Kiraz,1* Ilknur Dag,2 Mustafa Yamac,2 Abdurrahman Kiremitci,1 Nilgun Kasifoglu,1 and Yurdanur Akgun1

Department of Microbiology, Medical Faculty,1 Department of Biology, Faculty of Art and Science, University of Osmangazi, Eskisehir, Turkey2

Received 22 August 2008/ Returned for modification 29 September 2008/ Accepted 15 November 2008

The in vitro activities of caspofungin plus amphotericin B against 50 Candida glabrata isolates were evaluated by the time-kill, disk diffusion, and Etest methods. In vitro experiments showed a positive interaction. Even though each of these methods uses different conditions and endpoints, the results of the different methods frequently agreed.

* Corresponding author. Mailing address: Department of Microbiology, Medical Faculty, University of Osmangazi, Eskisehir, Turkey. Phone: 90-222-3104205. Fax: 90-222-2393772. E-mail: idag280{at}gmail.com

{triangledown} Published ahead of print on 24 November 2008.

Antimicrobial Agents and Chemotherapy, February 2009, p. 788-790, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.01131-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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