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Antimicrobial Agents and Chemotherapy, February 2009, p. 811-813, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.01150-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of the Quinolone WCK 771 against Recent U.S. Hospital and Community-Acquired Staphylococcus aureus Pathogens with Various Resistance Types{triangledown}

Sachin S. Bhagwat,1 Pamela McGhee,2 Klaudia Kosowska-Shick,2 Mahesh V. Patel,1 and Peter C. Appelbaum2*

Wockhardt Research Center, Aurangabad, India 431210,1 Hershey Medical Center, Hershey, Pennsylvania 170332

Received 27 August 2008/ Returned for modification 19 September 2008/ Accepted 17 November 2008

WCK 771 demonstrated MIC50 and MIC90s of 0.03 and 1 µg/ml, respectively, against 297 recent U.S. community-acquired and hospital strains of Staphylococcus aureus, irrespective of quinolone or glycopeptide resistance. Against quinolone-resistant strains, MIC90s of WCK 771 and moxifloxacin were 1 and 16 µg/ml, respectively.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.com

{triangledown} Published ahead of print on 24 November 2008.

Antimicrobial Agents and Chemotherapy, February 2009, p. 811-813, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.01150-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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