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Antimicrobial Agents and Chemotherapy, February 2009, p. 821-823, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.00132-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

SOS Regulation of qnrB Expression{triangledown}

Minghua Wang,1,2 George A. Jacoby,3* Debra M. Mills,3 and David C. Hooper1

Massachusetts General Hospital, Boston, Massachusetts,1 Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China,2 Lahey Clinic, Burlington, Massachusetts3

Received 30 January 2008/ Returned for modification 3 April 2008/ Accepted 12 November 2008

In the sequence upstream from qnrB (but not qnrA or qnrS) is a LexA binding site. qnrB was shown to be under SOS control by demonstrating that quinolone susceptibility decreased with increasing temperature in a strain with a recA441(Ts) allele, whereas qnrB expression increased in response to ciprofloxacin or mitomycin C in strains with an intact lexA gene.

* Corresponding author. Mailing address: 41 Mall Road, Burlington, MA 01805. Phone: (781) 744-2928. Fax: (781) 744-5486. E-mail: george.a.jacoby{at}lahey.org

{triangledown} Published ahead of print on 24 November 2008.

Antimicrobial Agents and Chemotherapy, February 2009, p. 821-823, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.00132-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Strahilevitz, J., Jacoby, G. A., Hooper, D. C., Robicsek, A. (2009). Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat. Clin. Microbiol. Rev. 22: 664-689 [Abstract] [Full Text]  
  • Rodriguez-Martinez, J. M., Briales, A., Velasco, C., Conejo, M. C., Martinez-Martinez, L., Pascual, A. (2009). Mutational analysis of quinolone resistance in the plasmid-encoded pentapeptide repeat proteins QnrA, QnrB and QnrS. J Antimicrob Chemother 63: 1128-1134 [Abstract] [Full Text]  


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