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Antimicrobial Agents and Chemotherapy, February 2009, p. 828-831, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.00927-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics and Bioequivalence Evaluation of Two Fixed-Dose Tablet Formulations of Dihydroartemisinin and Piperaquine in Vietnamese Subjects {triangledown}

Nguyen Trong Chinh,1 Nguyen Ngoc Quang,1 Nguyen Xuan Thanh,2 Bui Dai,2 Jason P. Geue,3 Russell S. Addison,3 Thomas Travers,4 and Michael D. Edstein4*

Department of Infectious Diseases, Military Hospital 108, Hanoi, Vietnam,1 Department of Malaria, Military Institute of Hygiene and Epidemiology, Hanoi, Vietnam,2 TetraQ, Royal Brisbane and Women's Hospital, Brisbane, Australia,3 Australian Army Malaria Institute, Brisbane, Australia4

Received 11 July 2008/ Returned for modification 3 November 2008/ Accepted 22 November 2008

The two fixed-dose combinations of dihydroartemisinin and piperaquine (Artekin and Arterakine) were found to be bioinequivalent in healthy Vietnamese subjects. However, because the peak plasma concentrations and areas under the concentration-time curves of dihydroartemisinin and piperaquine were only marginally different between the two formulations, similar therapeutic efficacies are expected in the treatment of malaria infections.

* Corresponding author. Mailing address: Australian Army Malaria Institute, Enoggera, Brisbane, QLD 4051, Australia. Phone: 61-7-33324801. Fax: 61-7-33324800. E-mail: mike.edstein{at}defence.gov.au

{triangledown} Published ahead of print on 1 December 2008.

Antimicrobial Agents and Chemotherapy, February 2009, p. 828-831, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.00927-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Nguyen, D. V. H., Nguyen, Q. P., Nguyen, N. D., Le, T. T. T., Nguyen, T. D., Dinh, D. N., Nguyen, T. X., Bui, D., Chavchich, M., Edstein, M. D. (2009). Pharmacokinetics and Ex Vivo Pharmacodynamic Antimalarial Activity of Dihydroartemisinin-Piperaquine in Patients with Uncomplicated Falciparum Malaria in Vietnam. Antimicrob. Agents Chemother. 53: 3534-3537 [Abstract] [Full Text]  


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