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Antimicrobial Agents and Chemotherapy, February 2009, p. 835-838, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.01233-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Susceptibility of Field Isolates of Leishmania donovani to Miltefosine and Amphotericin B: Correlation with Sodium Antimony Gluconate Susceptibility and Implications for Treatment in Areas of Endemicity{triangledown}

Dhiraj Kumar, Arpita Kulshrestha, Ruchi Singh,{dagger} and Poonam Salotra*

Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi, India

Received 17 September 2008/ Returned for modification 22 October 2008/ Accepted 10 November 2008

Indian Leishmania donovani isolates (n = 19) from regional zones representing various levels of antimony resistance displayed significantly (P < 0.01) correlated results with respect to in vitro susceptibility to the antileishmanial drugs sodium antimony gluconate, amphotericin B, and Miltefosine, raising the possibility of cross-resistance mechanisms operating in the field isolates. The results of gene expression analysis of LdMT and LdRos3 were suggestive of alternate mechanisms of Miltefosine susceptibility in the isolates.

* Corresponding author. Mailing address: Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi 110029, India. Phone: 91-11-2616 61 24. Fax: 91-11-2616 61 24. E-mail: salotra{at}vsnl.com

{triangledown} Published ahead of print on 17 November 2008.

{dagger} Present address: National Institute of Malaria Research (ICMR), Delhi, India.

Antimicrobial Agents and Chemotherapy, February 2009, p. 835-838, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.01233-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Vermeersch, M., da Luz, R. I., Tote, K., Timmermans, J.-P., Cos, P., Maes, L. (2009). In Vitro Susceptibilities of Leishmania donovani Promastigote and Amastigote Stages to Antileishmanial Reference Drugs: Practical Relevance of Stage-Specific Differences. Antimicrob. Agents Chemother. 53: 3855-3859 [Abstract] [Full Text]  


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